Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001273)
Formula
SVG example
O-Demethylation
Reactant Istradefylline Product 4'-O-monodesmethyl istradefylline
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - O-Demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001275 Istradefylline 1-beta-hydroxy-4'-O-demethyl Istradefylline Unclear Istradefylline [1]
MR001276 Istradefylline 1-beta-hydroxylated Istradefylline Oxidation - Hydroxylation Istradefylline [1]
MR001274 Istradefylline 3',4'-O-didemethyl Istradefylline Unclear Istradefylline [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001270 4'-O-monodesmethyl istradefylline Istradefylline M1 glucuronide Conjugation - O-Glucuronidation Istradefylline [1]
MR001271 4'-O-monodesmethyl istradefylline Istradefylline M1 sulfate conjugate Conjugation - Sulfation Istradefylline [1]
References
1 Effects of rifampin on the pharmacokinetics of a single dose of istradefylline in healthy subjects. J Clin Pharmacol. 2018 Feb;58(2):193-201.

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