Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001276)
Formula
CYP3A4 ...
SVG example
Hydroxylation
Reactant Istradefylline Product 1-beta-hydroxylated Istradefylline
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001275 Istradefylline 1-beta-hydroxy-4'-O-demethyl Istradefylline Unclear Istradefylline [1]
MR001274 Istradefylline 3',4'-O-didemethyl Istradefylline Unclear Istradefylline [1]
MR001273 Istradefylline 4'-O-monodesmethyl istradefylline Oxidation - O-Demethylation Istradefylline [1], [2]
References
1 Effects of rifampin on the pharmacokinetics of a single dose of istradefylline in healthy subjects. J Clin Pharmacol. 2018 Feb;58(2):193-201.
2 The effect of CYP3A4 genetic polymorphism and drug interaction on the metabolism of istradefylline Chem Biol Interact. 2022 Oct 1;366:110123. doi: 10.1016/j.cbi.2022.110123.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.