Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001277)
Formula
SVG example
O-Demethylation
Reactant Itraconazole Product Hydroxyitraconazole
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - O-Demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001278 Itraconazole Keto-itraconazole Unclear Itraconazole [1], [2]
MR001279 Itraconazole N-desalkyl-itraconazole Oxidation - N-Dealkylation Itraconazole [1], [2]
References
1 Role of itraconazole metabolites in CYP3A4 inhibition. Drug Metab Dispos. 2004 Oct;32(10):1121-31.
2 Accurate prediction of dose-dependent CYP3A4 inhibition by itraconazole and its metabolites from in vitro inhibition data Clin Pharmacol Ther. 2010 Oct;88(4):499-505. doi: 10.1038/clpt.2010.119.

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