Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001333)
Formula Reactant Norketobemidone Product Dihydroxy norketobemidone
Reactant Info Product Info
Metabolic Type Oxidation - 4'-Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001336 Ketobemidone Norketobemidone Oxidation - N-Demethylation Ketobemidone [1], [2]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001334 Norketobemidone Norketobemidone glucuronide metabolite Unclear Ketobemidone [3]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
2 Ketobemidone is a substrate for cytochrome P4502C9 and 3A4, but not for P-glycoprotein. Xenobiotica. 2005 Aug;35(8):785-96.
3 In vivo investigation of brain and systemic ketobemidone metabolism Analyst. 2010 Feb;135(2):405-13. doi: 10.1039/b917940b.

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