Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001336)
Formula
CYP2C9 ...
SVG example
N-Demethylation
Reactant Ketobemidone Product Norketobemidone
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2C9 (CYP2C9) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - N-Demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001335 Ketobemidone Dihydroxy ketobemidone Unclear Ketobemidone [1]
MR001338 Ketobemidone Ketobemidone N-oxide metabolite Oxidation - N-Oxidation Ketobemidone [2]
MR001337 Ketobemidone Reduced ketobemidone Reduction - Reduction Ketobemidone [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001333 Norketobemidone Dihydroxy norketobemidone Oxidation - 4'-Hydroxylation Ketobemidone [1]
MR001334 Norketobemidone Norketobemidone glucuronide metabolite Unclear Ketobemidone [4]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
2 Quantitative determination of the urinary excretion of ketobemidone and four of its metabolites after intravenous and oral administration in man Drug Metab Dispos. 1981 Jul-Aug;9(4):376-80.
3 DrugBank(Pharmacology-Metabolism)Ketobemidone hydrochloride
4 In vivo investigation of brain and systemic ketobemidone metabolism Analyst. 2010 Feb;135(2):405-13. doi: 10.1039/b917940b.

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