Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001356)
Formula Reactant Ketoconazole Product M9 (Ketoconazole)
Reactant Info Product Info
Metabolic Type Oxidation - Hydoxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001357 Ketoconazole Ketoconazole epoxide intermediate Unclear Ketoconazole [1]
MR001352 Ketoconazole M13 (Ketoconazole) Oxidation - N-Oxidation Ketoconazole [1]
MR001353 Ketoconazole M14 (Ketoconazole) Oxidation - Deacetylation Ketoconazole [1]
MR001354 Ketoconazole M7 (Ketoconazole) Oxidation - Oxidation Ketoconazole [1]
MR001355 Ketoconazole M8 (Ketoconazole) Oxidation - Hydroxylation Ketoconazole [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001341 M9 (Ketoconazole) Ketoconazole iminium ion Other reaction - Dehydration Ketoconazole [1]
MR001340 M9 (Ketoconazole) M10 (Ketoconazole) Oxidation - N-Dealkylation Ketoconazole [1]
MR001342 M9 (Ketoconazole) M12 (Ketoconazole) Oxidation - Oxidation Ketoconazole [1]
References
1 Revisiting the metabolism of ketoconazole using accurate mass Drug Metab Lett. 2009 Aug;3(3):191-8. doi: 10.2174/187231209789352085.

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