Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001361)
Formula Reactant 2-[3-(3-hydroxybenzoyl) phenyl]-propanoic acid Product Ketoprofen metabolite 4
Reactant Info Product Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001364 Ketoprofen 2-[3-(3-hydroxybenzoyl) phenyl]-propanoic acid Oxidation - Hydroxylation Ketoprofen [1], [2]
MR013740 R-ketoprofen 3-Hydroxy ketoprofen Oxidation - Hydroxylation R-ketoprofen [3]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001360 2-[3-(3-hydroxybenzoyl) phenyl]-propanoic acid Ketoprofen metabolite 2 Conjugation - Glucuronidation Ketoprofen [1], [2]
References
1 Clinical pharmacokinetics of ketoprofen enantiomers in wild type of Cyp 2c8 and Cyp 2c9 patients with rheumatoid arthritis. Eur J Drug Metab Pharmacokinet. 2011 Sep;36(3):167-73.
2 Characterization and quantification of metabolites of racemic ketoprofen excreted in urine following oral administration to man by 1H-NMR spectroscopy, directly coupled HPLC-MS and HPLC-NMR, and circular dichroism Xenobiotica. 2004 Nov-Dec;34(11-12):1075-89. doi: 10.1080/00498250412331281098.
3 Ketoprofen in horses: Metabolism, pharmacokinetics, and effects on inflammatory biomarkers

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