Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001364)
Formula
CYP2C8 ...
SVG example
Hydroxylation
Reactant Ketoprofen Product 2-[3-(3-hydroxybenzoyl) phenyl]-propanoic acid
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2C8 (CYP2C8) DME Info
Cytochrome P450 2C9 (CYP2C9) DME Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001363 Ketoprofen 2-[3-(4-hydroxybenzoyl) phenyl]-propanoic acid Oxidation - Hydroxylation Ketoprofen [1], [2]
MR001365 Ketoprofen 2-[3-(hydroxy(phenyl)methyl) phenyl]-propanoic acid Oxidation - Hydroxylation Ketoprofen [1], [2]
MR001366 Ketoprofen Ketoprofen glucuronide Conjugation - Glucuronidation Ketoprofen [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013740 R-ketoprofen 3-Hydroxy ketoprofen Oxidation - Hydroxylation R-ketoprofen [3]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001360 2-[3-(3-hydroxybenzoyl) phenyl]-propanoic acid Ketoprofen metabolite 2 Conjugation - Glucuronidation Ketoprofen [1], [2]
MR001361 2-[3-(3-hydroxybenzoyl) phenyl]-propanoic acid Ketoprofen metabolite 4 Conjugation - Glucuronidation Ketoprofen [1], [2]
References
1 Clinical pharmacokinetics of ketoprofen enantiomers in wild type of Cyp 2c8 and Cyp 2c9 patients with rheumatoid arthritis. Eur J Drug Metab Pharmacokinet. 2011 Sep;36(3):167-73.
2 Characterization and quantification of metabolites of racemic ketoprofen excreted in urine following oral administration to man by 1H-NMR spectroscopy, directly coupled HPLC-MS and HPLC-NMR, and circular dichroism Xenobiotica. 2004 Nov-Dec;34(11-12):1075-89. doi: 10.1080/00498250412331281098.
3 Ketoprofen in horses: Metabolism, pharmacokinetics, and effects on inflammatory biomarkers

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