Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013740)
Formula Reactant R-ketoprofen Product 3-Hydroxy ketoprofen
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 family 2 subfamily C member 23 (CYP2C23) DME Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013738 R-ketoprofen (S)-ketoprofen Unclear R-ketoprofen [1]
MR013739 R-ketoprofen R-ketoprofen metabolite M1 Conjugation - Glucuronidation R-ketoprofen [2], [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001364 Ketoprofen 2-[3-(3-hydroxybenzoyl) phenyl]-propanoic acid Oxidation - Hydroxylation Ketoprofen [4], [5]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001360 2-[3-(3-hydroxybenzoyl) phenyl]-propanoic acid Ketoprofen metabolite 2 Conjugation - Glucuronidation Ketoprofen [4], [5]
MR001361 2-[3-(3-hydroxybenzoyl) phenyl]-propanoic acid Ketoprofen metabolite 4 Conjugation - Glucuronidation Ketoprofen [4], [5]
References
1 Inversion of (R)- to (S)-ketoprofen in eight animal species
2 High-performance liquid chromatographic enantioselective assay for the measurement of ketoprofen glucuronidation by liver microsomes
3 Ketoprofen in horses: Metabolism, pharmacokinetics, and effects on inflammatory biomarkers
4 Clinical pharmacokinetics of ketoprofen enantiomers in wild type of Cyp 2c8 and Cyp 2c9 patients with rheumatoid arthritis. Eur J Drug Metab Pharmacokinet. 2011 Sep;36(3):167-73.
5 Characterization and quantification of metabolites of racemic ketoprofen excreted in urine following oral administration to man by 1H-NMR spectroscopy, directly coupled HPLC-MS and HPLC-NMR, and circular dichroism Xenobiotica. 2004 Nov-Dec;34(11-12):1075-89. doi: 10.1080/00498250412331281098.

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