Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001429)
Formula Reactant Lapatinib ditosylate Product N-hydroxy lapatinib
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Metabolic Type Oxidation - N-Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001430 Lapatinib ditosylate GW42393 Unclear Lapatinib ditosylate [1]
MR001431 Lapatinib ditosylate GW690006 Unclear Lapatinib ditosylate [1]
MR001428 Lapatinib ditosylate N-dealkylated lapatinib Oxidation - N-Dealkylation Lapatinib ditosylate [1]
MR001427 Lapatinib ditosylate O-dealkylated lapatinib Oxidation - O-Dealkylation Lapatinib ditosylate [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001423 N-hydroxy lapatinib Nitroso intermediate Unclear Lapatinib ditosylate [1]
References
1 Metabolic intermediate complex formation of human cytochrome P450 3A4 by lapatinib Drug Metab Dispos. 2011 Jun;39(6):1022-30. doi: 10.1124/dmd.110.037531.

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