Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR008915)
Formula
MAO
SVG example
Unclear
Reactant Dopamine Product 3,4-dihydroxyphenylacetic acid
Reactant Info Product Info
Metabolic Enzyme Monoamine oxidase (MAO) DME Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001498 Levodopa Dopamine Oxidation - Decarboxylation Levodopa [1]
MR008912 DEC-TA-870 Dopamine Unclear - Unclear Docarpamine [2]
MR009124 Levodopa Dopamine Unclear - Unclear ABBV-951 [3]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001486 Dopamine 3,4-Dihydroxyphenylacetaldehyde (DOPAL) Oxidation - Oxidative Deamination Levodopa [4]
MR001485 Dopamine 3-Methoxytyramine Conjugation - O-Methylation Levodopa [4]
MR001488 Dopamine Dopamine-3-O-glucuronide Oxidation - N-Dealkylation Levodopa [4]
MR001490 Dopamine Dopamine-3-O-sulfate Conjugation - Sulfation Levodopa [4]
MR001489 Dopamine Dopamine-4-O-glucuronide Oxidation - N-Dealkylation Levodopa [4]
MR001491 Dopamine Dopamine-4-O-sulfate Conjugation - Sulfation Levodopa [4]
MR001487 Dopamine Norepinephrine Oxidation - Hydroxylation Levodopa [4]
MR008913 Dopamine 3-methoxytyramine Unclear - Unclear Docarpamine [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006362 SC-47945 DOPAC Unclear SC-47945 [5]
MR006627 DHPA DOPAC Unclear Dopamine hydrochloride [6]
MR001494 3,4-Dihydroxyphenylacetaldehyde (DOPAL) 3,4-dihydroxyphenylacetic acid Oxidation - Hydroxylation Levodopa [4]
MR004488 3-(3',4'-Dihydroxyphenyl)propionic acid 3'-4'-Dihydroxyphenylacetic acid Unclear VS-12343 [7]
MR003506 DOPL 3,4-dihydroxyphenylacetic acid Unclear L-phenylalanine [8]
MR004403 2-(4-Hydroxyphenyl)acetic acid (3,4-Dihydroxyphenyl)acetic acid Oxidation - Hydrolyzationn N-nonylphenol [9]
⏷ Show the Full List of MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006363 DOPAC HVA Unclear SC-47945 [5]
MR006365 DOPAC Sulfate conjugate of DOPAC Unclear SC-47945 [5]
MR006628 DOPAC HVA Unclear Dopamine hydrochloride [6]
MR008916 3,4-dihydroxyphenylacetic acid 3-hydroxyphenylacetic acid Unclear - Unclear Docarpamine [2]
MR001496 3,4-dihydroxyphenylacetic acid Homovanillic acid Conjugation - O-Methylation Levodopa [4]
MR004489 3'-4'-Dihydroxyphenylacetic acid 3'-Hydroxyphenylacetic acid Unclear VS-12343 [7]
MR003507 3,4-dihydroxyphenylacetic acid 3,4-Dihydroxybenzoic acid Unclear L-phenylalanine [8]
MR004494 3'-4'-Dihydroxyphenylacetic acid 3,4-Dihydroxybenzoic acid Unclear VS-12343 [7]
⏷ Show the Full List of MR
References
1 Complexity of dopamine metabolism. Cell Commun Signal. 2013 May 17;11(1):34.
2 Metabolism of a new orally active dopamine prodrug, N-(N-acetyl-L-methionyl)-O,O-bis(ethoxycarbonyl)dopamine (TA-870) and dopamine after oral administration to rats and dogs
3 Scalable Asymmetric Syntheses of Foslevodopa and Foscarbidopa Drug Substances for the Treatment of Parkinson's Disease
4 DrugBank(Pharmacology-Metabolism)Levodopa
5 Neurotoxicity and metabolism of the catecholamine-derived 3,4-dihydroxyphenylacetaldehyde and 3,4-dihydroxyphenylglycolaldehyde: the role of aldehyde dehydrogenase. Pharmacol Rev. 2007 Jun;59(2):125-50.
6 Membrane bound catechol-O-methytransferase is the dominant isoform for dopamine metabolism in PC12 cells and rat brain
7 Biotransformation of two citrus flavanones by lactic acid bacteria in chemical defined medium
8 Catabolism of L-phenylalanine and L-tyrosine by Rhodobacter sphaeroides OU5 occurs through 3,4-dihydroxyphenylalanine Res Microbiol. 2007 Jul-Aug;158(6):506-11. doi: 10.1016/j.resmic.2007.04.008.
9 4-n-nonylphenol degradation by the genus Metarhizium with cytochrome P450 involvement

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