Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001518)
Formula
SVG example
Deiodination
Reactant Levothyroxine sodium Product Reverse triiodothyronine
Reactant Info Product Info
Metabolic Enzyme Thyroxine 5-deiodinase (DIO3) DME Info
Metabolic Type Oxidation - Deiodination
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001517 Levothyroxine sodium 3,3',5-triiodothyronine Oxidation - Deiodination Levothyroxine sodium [1]
MR001519 Levothyroxine sodium Levothyroxine glucuronide Conjugation - Conjugation Levothyroxine sodium [2]
MR001520 Levothyroxine sodium Levothyroxine sulfate Conjugation - Conjugation Levothyroxine sodium [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005866 Liothyronine Reverse triiodothyronine Unclear L-thyroxine [3]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001516 Reverse triiodothyronine Diiodothyronine Oxidation - Deiodination Levothyroxine sodium [2]
References
1 Local activation and inactivation of thyroid hormones: the deiodinase family Mol Cell Endocrinol. 1999 May 25;151(1-2):103-19. doi: 10.1016/s0303-7207(99)00040-4.
2 LABEL:EVOTHYROXINE SODIUM injection
3 Lipoatrophic diabetes: endocrine dysfunction and the response to control hypertriglyceridemia

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.