Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001517)
Formula
SVG example
Deiodination
Reactant Levothyroxine sodium Product 3,3',5-triiodothyronine
Reactant Info Product Info
Metabolic Enzyme Thyroxine 5-deiodinase (DIO3) DME Info
Metabolic Type Oxidation - Deiodination
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001519 Levothyroxine sodium Levothyroxine glucuronide Conjugation - Conjugation Levothyroxine sodium [1]
MR001520 Levothyroxine sodium Levothyroxine sulfate Conjugation - Conjugation Levothyroxine sodium [1]
MR001518 Levothyroxine sodium Reverse triiodothyronine Oxidation - Deiodination Levothyroxine sodium [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001515 3,3',5-triiodothyronine Diiodothyronine Oxidation - Deiodination Levothyroxine sodium [1], [3], [4]
References
1 LABEL:EVOTHYROXINE SODIUM injection
2 Local activation and inactivation of thyroid hormones: the deiodinase family Mol Cell Endocrinol. 1999 May 25;151(1-2):103-19. doi: 10.1016/s0303-7207(99)00040-4.
3 Development of a microphysiological skin-liver-thyroid Chip3 model and its application to evaluate the effects on thyroid hormones of topically applied cosmetic ingredients under consumer-relevant conditions. Front Pharmacol. 2023 Feb 8;14:1076254. doi: 10.3389/fphar.2023.1076254.
4 Role and Clinical Significance of Monocarboxylate Transporter 8 (MCT8) During Pregnancy. Reprod Sci. 2023 Jun;30(6):1758-1769. doi: 10.1007/s43032-022-01162-z.

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