Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001531)
Formula
SVG example
Reactant Alpha-ketoglutarate Product Malate
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001522 L-glutamate Alpha-ketoglutarate Hydrolysis - Hydrolyzation L-glutamine [1], [2], [3]
MR012762 Glutamate Alpha-ketoglutarate Unclear - Unclear Gamma hydroxybutyric acid [4]
MR008810 L-Glutamate Alpha-ketoglutarate Unclear - Unclear L-Proline [5]
MR012745 L-Glutamate Alpha-Ketoglutarate Unclear - Unclear Arginine [6]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001528 Alpha-ketoglutarate Aspartate Unclear L-glutamine [7]
MR001530 Alpha-ketoglutarate Citrate Unclear L-glutamine [7]
MR001529 Alpha-ketoglutarate Mammalian target of rapamycin Unclear L-glutamine [7]
MR012763 Alpha-ketoglutarate Isocitrate Unclear - Unclear Gamma hydroxybutyric acid [4]
MR012766 Alpha-ketoglutarate Succinyl-coA Unclear - Unclear Gamma hydroxybutyric acid [4]
References
1 -KG inhibits tumor growth of diffuse large B-cell lymphoma by inducing ROS and TP53-mediated ferroptosis. Cell Death Discov. 2023 Jun 12;9(1):182. doi: 10.1038/s41420-023-01475-1.
2 The delta subunit of the GABA(A) receptor is necessary for the GPT2-promoted breast cancer metastasis. Theranostics. 2023 Feb 21;13(4):1355-1369. doi: 10.7150/thno.80544.
3 The helminth derived peptide FhHDM-1 redirects macrophage metabolism towards glutaminolysis to regulate the pro-inflammatory response. Front Immunol. 2023 Jan 25;14:1018076. doi: 10.3389/fimmu.2023.1018076.
4 U. S. FDA Label -Gamma hydroxybutyric acid
5 Proline Metabolism in Cell Regulation and Cancer Biology: Recent Advances and Hypotheses
6 Arginine Metabolism Revisited
7 The Emerging Role of l-Glutamine in Cardiovascular Health and Disease Nutrients. 2019 Sep 4;11(9):2092. doi: 10.3390/nu11092092.

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