Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR012766)
Formula
SVG example
Unclear
Reactant Alpha-ketoglutarate Product Succinyl-coA
Reactant Info Product Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001522 L-glutamate Alpha-ketoglutarate Hydrolysis - Hydrolyzation L-glutamine [1], [2], [3]
MR012762 Glutamate Alpha-ketoglutarate Unclear - Unclear Gamma hydroxybutyric acid [4]
MR008810 L-Glutamate Alpha-ketoglutarate Unclear - Unclear L-Proline [5]
MR012745 L-Glutamate Alpha-Ketoglutarate Unclear - Unclear Arginine [6]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001528 Alpha-ketoglutarate Aspartate Unclear L-glutamine [7]
MR001530 Alpha-ketoglutarate Citrate Unclear L-glutamine [7]
MR001531 Alpha-ketoglutarate Malate Unclear L-glutamine [7]
MR001529 Alpha-ketoglutarate Mammalian target of rapamycin Unclear L-glutamine [7]
MR012763 Alpha-ketoglutarate Isocitrate Unclear - Unclear Gamma hydroxybutyric acid [4]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012770 Succinate Succinyl-coA Unclear - Unclear Gamma hydroxybutyric acid [4]
MR003882 A-ketoglutarate Succinyl-coA Unclear DB-053072 [8]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012767 Succinyl-coA Succinyicamitine Unclear - Unclear Gamma hydroxybutyric acid [4]
MR003883 Succinyl-coA Succinate Unclear DB-053072 [8]
References
1 -KG inhibits tumor growth of diffuse large B-cell lymphoma by inducing ROS and TP53-mediated ferroptosis. Cell Death Discov. 2023 Jun 12;9(1):182. doi: 10.1038/s41420-023-01475-1.
2 The delta subunit of the GABA(A) receptor is necessary for the GPT2-promoted breast cancer metastasis. Theranostics. 2023 Feb 21;13(4):1355-1369. doi: 10.7150/thno.80544.
3 The helminth derived peptide FhHDM-1 redirects macrophage metabolism towards glutaminolysis to regulate the pro-inflammatory response. Front Immunol. 2023 Jan 25;14:1018076. doi: 10.3389/fimmu.2023.1018076.
4 U. S. FDA Label -Gamma hydroxybutyric acid
5 Proline Metabolism in Cell Regulation and Cancer Biology: Recent Advances and Hypotheses
6 Arginine Metabolism Revisited
7 The Emerging Role of l-Glutamine in Cardiovascular Health and Disease Nutrients. 2019 Sep 4;11(9):2092. doi: 10.3390/nu11092092.
8 Metabolic analysis of 13C-labeled pyruvate for noninvasive assessment of mitochondrial function

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