Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001566)
Formula
SVG example
Reactant Linagliptin Product Linagliptin M515
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001565 Linagliptin Linagliptin CD10604 Oxidation - Oxidation Linagliptin [1], [2]
MR001570 Linagliptin Linagliptin M487(1) Reduction - Reduction Linagliptin [2]
MR001567 Linagliptin Linagliptin M489(1) Oxidation - Hydroxylation Linagliptin [2]
MR001569 Linagliptin Linagliptin M503(1) Unclear Linagliptin [2]
MR001571 Linagliptin M665(3) Conjugation - Glucuronidation Linagliptin [2]
MR001572 Linagliptin M665(8) Conjugation - Glucuronidation Linagliptin [2]
MR001568 Linagliptin N-acetylcyteine M636 Conjugation - N-Acetylation Linagliptin [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001562 Linagliptin M515 Linagliptin M531(1) Oxidation - Hydroxylation Linagliptin [2]
MR001561 Linagliptin M515 Linagliptin M531(2) Oxidation - Hydroxylation Linagliptin [2]
References
1 Clinical pharmacokinetics and pharmacodynamics of linagliptin Clin Pharmacokinet. 2012 Jul 1;51(7):411-27. doi: 10.2165/11630900-000000000-00000.
2 The metabolism and disposition of the oral dipeptidyl peptidase-4 inhibitor, linagliptin, in humans Drug Metab Dispos. 2010 Apr;38(4):667-78. doi: 10.1124/dmd.109.031476.

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