Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001570)
Formula
SVG example
Reduction
Reactant Linagliptin Product Linagliptin M487(1)
Reactant Info Product Info
Metabolic Type Reduction - Reduction
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001565 Linagliptin Linagliptin CD10604 Oxidation - Oxidation Linagliptin [1], [2]
MR001567 Linagliptin Linagliptin M489(1) Oxidation - Hydroxylation Linagliptin [2]
MR001569 Linagliptin Linagliptin M503(1) Unclear Linagliptin [2]
MR001566 Linagliptin Linagliptin M515 Unclear Linagliptin [2]
MR001571 Linagliptin M665(3) Conjugation - Glucuronidation Linagliptin [2]
MR001572 Linagliptin M665(8) Conjugation - Glucuronidation Linagliptin [2]
MR001568 Linagliptin N-acetylcyteine M636 Conjugation - N-Acetylation Linagliptin [2]
References
1 Clinical pharmacokinetics and pharmacodynamics of linagliptin Clin Pharmacokinet. 2012 Jul 1;51(7):411-27. doi: 10.2165/11630900-000000000-00000.
2 The metabolism and disposition of the oral dipeptidyl peptidase-4 inhibitor, linagliptin, in humans Drug Metab Dispos. 2010 Apr;38(4):667-78. doi: 10.1124/dmd.109.031476.

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