Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001605)
Formula Reactant Norethindrone Product Lynestrenol metabolite M1/Lynestrenol metaboliteM2
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010809 Norethindrone 3alpha-NET Unclear - Unclear Norethindrone [1]
MR010818 Norethindrone 3beta-NET Unclear - Unclear Norethindrone [1]
MR010812 Norethindrone 5alpha-NET Unclear - Unclear Norethindrone [1]
MR010815 Norethindrone 5beta-NET Unclear - Unclear Norethindrone [1]
MR001606 Norethindrone Lynestrenol metabolite M4 Oxidation - Dehydrogenation Lynestrenol [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001607 Lynestrenol metabolite M1/Lynestrenol metaboliteM2 Lynestrenol metabolite M3 Oxidation - Dihydroxylation Lynestrenol [2]
MR001608 Lynestrenol metabolite M1/Lynestrenol metaboliteM2 Lynestrenol metabolite M4 Unclear Lynestrenol [2]
References
1 Hormonal properties of norethisterone, 7alpha-methyl-norethisterone and their derivatives. J Steroid Biochem Mol Biol. 2000 Nov 15;74(4):213-22.
2 Identification of the human cytochrome P450 enzymes involved in the in vitro biotransformation of lynestrenol and norethindrone. J Steroid Biochem Mol Biol. 2008 May;110(1-2):56-66.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.