Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001606)
Formula Reactant Norethindrone Product Lynestrenol metabolite M4
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - Dehydrogenation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010809 Norethindrone 3alpha-NET Unclear - Unclear Norethindrone [1]
MR010818 Norethindrone 3beta-NET Unclear - Unclear Norethindrone [1]
MR010812 Norethindrone 5alpha-NET Unclear - Unclear Norethindrone [1]
MR010815 Norethindrone 5beta-NET Unclear - Unclear Norethindrone [1]
MR001605 Norethindrone Lynestrenol metabolite M1/Lynestrenol metaboliteM2 Oxidation - Hydroxylation Lynestrenol [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001608 Lynestrenol metabolite M1/Lynestrenol metaboliteM2 Lynestrenol metabolite M4 Unclear Lynestrenol [2]
References
1 Hormonal properties of norethisterone, 7alpha-methyl-norethisterone and their derivatives. J Steroid Biochem Mol Biol. 2000 Nov 15;74(4):213-22.
2 Identification of the human cytochrome P450 enzymes involved in the in vitro biotransformation of lynestrenol and norethindrone. J Steroid Biochem Mol Biol. 2008 May;110(1-2):56-66.

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