Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001631)
Formula
CYP2C8 ...
SVG example
N-Glucuronidation
Reactant Mefenamic acid Product Mefenamic acyl-beta-D-glucuronide
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2C8 (CYP2C8) DME Info
UDP-glucuronyltransferase (UGT) DME Info
Metabolic Type Conjugation - N-Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001630 Mefenamic acid 3-hydroxymethyl Mefenamic Acid Oxidation - Hydroxylation Mefenamic acid [1]
References
1 Cytochrome P450-mediated bioactivation of mefenamic acid to quinoneimine intermediates and inactivation by human glutathione S-transferases. Chem Res Toxicol. 2014 Dec 15;27(12):2071-81.

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