Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001630)
Formula
SVG example
Hydroxylation
Reactant Mefenamic acid Product 3-hydroxymethyl Mefenamic Acid
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2C9 (CYP2C9) DME Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001631 Mefenamic acid Mefenamic acyl-beta-D-glucuronide Conjugation - N-Glucuronidation Mefenamic acid [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001613 Meclofenamic acid 3-hydroxymethyl Mefenamic Acid Oxidation - Hydroxylation Meclofenamic acid [2], [3]
References
1 Role of cytochrome P450 2C8 in drug metabolism and interactions. Pharmacol Rev. 2016 Jan;68(1):168-241.
2 Both reactivity and accessibility are important in cytochrome P450 metabolism: a combined DFT and MD study of fenamic acids in BM3 mutants. J Chem Inf Model. 2019 Feb 25;59(2):743-753.
3 Metabolism of non-steroidal anti-inflammatory drugs (NSAIDs) by Streptomyces griseolus CYP105A1 and its variants Drug Metab Pharmacokinet. 2022 Aug;45:100455. doi: 10.1016/j.dmpk.2022.100455.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.