Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001632)
Formula
SVG example
N-Demethylation
Reactant Mefloquine hydrochloride Product 2,8-Bis(trifluoromethyl)quinoline-4-carboxylic acid
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - N-Demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001633 Mefloquine hydrochloride Alcohol Unclear Mefloquine hydrochloride [1]
References
1 Effect of rifampin on plasma concentrations of mefloquine in healthy volunteers. J Pharm Pharmacol. 2000 Oct;52(10):1265-9.

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