Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001656)
Formula Reactant N-Desmethylaminopyrine Product Arachidonoyl-4-methylaminoantipyrinee (ARA-4-MAA)
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000170 Aminophenazone N-Desmethylaminopyrine Oxidation - N-Dealkylation Aminophenazone [1]
MR001660 Metamizole sodium N-Desmethylaminopyrine Hydrolysis - Hydrolysis Metamizole sodium [2], [3]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001655 N-Desmethylaminopyrine 4-amino-antipyrine (AA) Oxidation - N-Demethylation Metamizole sodium [2], [3]
MR001654 N-Desmethylaminopyrine 4-formyl-amino-antipyrine (FAA) Oxidation - C-Oxidation Metamizole sodium [2], [3]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
2 Metamizole (Dipyrone) and the Liver: A Review of the Literature J Clin Pharmacol. 2019 Nov;59(11):1433-1442. doi: 10.1002/jcph.1512.
3 Clinical pharmacokinetics of dipyrone and its metabolites Clin Pharmacokinet. 1995 Mar;28(3):216-34. doi: 10.2165/00003088-199528030-00004.

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