Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001655)
Formula
CYP2B6 ...
SVG example
N-Demethylation
Reactant N-Desmethylaminopyrine Product 4-amino-antipyrine (AA)
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2B6 (CYP2B6) DME Info
Cytochrome P450 2C8 (CYP2C8) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2C9 (CYP2C9) DME Info
Metabolic Type Oxidation - N-Demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000170 Aminophenazone N-Desmethylaminopyrine Oxidation - N-Dealkylation Aminophenazone [1]
MR001660 Metamizole sodium N-Desmethylaminopyrine Hydrolysis - Hydrolysis Metamizole sodium [2], [3]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001654 N-Desmethylaminopyrine 4-formyl-amino-antipyrine (FAA) Oxidation - C-Oxidation Metamizole sodium [2], [3]
MR001656 N-Desmethylaminopyrine Arachidonoyl-4-methylaminoantipyrinee (ARA-4-MAA) Unclear Metamizole sodium [2], [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001657 4-formyl-amino-antipyrine (FAA) 4-amino-antipyrine (AA) Oxidation - N-Demethylation Metamizole sodium [2], [3]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001658 4-amino-antipyrine (AA) 4-acetyl-amino-antipyrine (AAA) Conjugation - Acetylation Metamizole sodium [2], [3]
MR001659 4-amino-antipyrine (AA) Arachidonoyl-4-aminoantipyrine (ARA-4-AA) Unclear Metamizole sodium [2], [3]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
2 Metamizole (Dipyrone) and the Liver: A Review of the Literature J Clin Pharmacol. 2019 Nov;59(11):1433-1442. doi: 10.1002/jcph.1512.
3 Clinical pharmacokinetics of dipyrone and its metabolites Clin Pharmacokinet. 1995 Mar;28(3):216-34. doi: 10.2165/00003088-199528030-00004.

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