Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000170)
Formula
CYP1A2 ...
SVG example
N-Dealkylation
Reactant Aminophenazone Product N-Desmethylaminopyrine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 1A2 (CYP1A2) DME Info
Cytochrome P450 3A43 (CYP3A43) DME Info
Cytochrome P450 2C18 (CYP2C18) DME Info
Cytochrome P450 2C18 (CYP2C18) DME Info
Cytochrome P450 2C8 (CYP2C8) DME Info
Cytochrome P450 2C18 (CYP2C18) DME Info
Cytochrome P450 2D6 (CYP2D6) DME Info
Metabolic Type Oxidation - N-Dealkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000169 Aminophenazone 4-(Dimethylamino)-5-methyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one Oxidation - N-Dealkylation Aminophenazone [1]
MR000168 Aminophenazone Aminophenazone metabolite I Unclear Aminophenazone [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001660 Metamizole sodium N-Desmethylaminopyrine Hydrolysis - Hydrolysis Metamizole sodium [3], [4]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001655 N-Desmethylaminopyrine 4-amino-antipyrine (AA) Oxidation - N-Demethylation Metamizole sodium [3], [4]
MR001654 N-Desmethylaminopyrine 4-formyl-amino-antipyrine (FAA) Oxidation - C-Oxidation Metamizole sodium [3], [4]
MR001656 N-Desmethylaminopyrine Arachidonoyl-4-methylaminoantipyrinee (ARA-4-MAA) Unclear Metamizole sodium [3], [4]
References
1 Cytochromes P450: a structure-based summary of biotransformations using representative substrates Drug Metab Rev. 2008;40(1):1-100. doi: 10.1080/03602530802309742.
2 U. S. FDA Label - Aminophenazone
3 Metamizole (Dipyrone) and the Liver: A Review of the Literature J Clin Pharmacol. 2019 Nov;59(11):1433-1442. doi: 10.1002/jcph.1512.
4 Clinical pharmacokinetics of dipyrone and its metabolites Clin Pharmacokinet. 1995 Mar;28(3):216-34. doi: 10.2165/00003088-199528030-00004.

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