Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001726)
Formula Reactant Neratinib Product Neratinib metabolite M10
Reactant Info Product Info
Metabolic Type Oxidation - N-Demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001728 Neratinib Neratinib metabolite M12 Oxidation - N-Oxygenation Neratinib [1]
MR001727 Neratinib Neratinib metabolite M3 Oxidation - O-Dealkylation Neratinib [1]
MR001724 Neratinib Neratinib metabolite M6,M7 Conjugation - Glutathione Conjugation Neratinib [1]
MR001725 Neratinib Neratinib metabolite M8 Oxidation - Oxygenation Neratinib [1]
References
1 Metabolic profiles of neratinib in rat by using ultra-high-performance liquid chromatography coupled with diode array detector and Q-Exactive Orbitrap tandem mass spectrometry Biomed Chromatogr. 2018 May 3:e4272. doi: 10.1002/bmc.4272.

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