Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001725)
Formula
SVG example
Oxygenation
Reactant Neratinib Product Neratinib metabolite M8
Reactant Info Product Info
Metabolic Type Oxidation - Oxygenation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001726 Neratinib Neratinib metabolite M10 Oxidation - N-Demethylation Neratinib [1]
MR001728 Neratinib Neratinib metabolite M12 Oxidation - N-Oxygenation Neratinib [1]
MR001727 Neratinib Neratinib metabolite M3 Oxidation - O-Dealkylation Neratinib [1]
MR001724 Neratinib Neratinib metabolite M6,M7 Conjugation - Glutathione Conjugation Neratinib [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001723 Neratinib metabolite M8 Neratinib metabolite M4,M5 Conjugation - Glutathione Conjugation Neratinib [1]
References
1 Metabolic profiles of neratinib in rat by using ultra-high-performance liquid chromatography coupled with diode array detector and Q-Exactive Orbitrap tandem mass spectrometry Biomed Chromatogr. 2018 May 3:e4272. doi: 10.1002/bmc.4272.

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