Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001727)
Formula
SVG example
O-Dealkylation
Reactant Neratinib Product Neratinib metabolite M3
Reactant Info Product Info
Metabolic Type Oxidation - O-Dealkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001726 Neratinib Neratinib metabolite M10 Oxidation - N-Demethylation Neratinib [1]
MR001728 Neratinib Neratinib metabolite M12 Oxidation - N-Oxygenation Neratinib [1]
MR001724 Neratinib Neratinib metabolite M6,M7 Conjugation - Glutathione Conjugation Neratinib [1]
MR001725 Neratinib Neratinib metabolite M8 Oxidation - Oxygenation Neratinib [1]
References
1 Metabolic profiles of neratinib in rat by using ultra-high-performance liquid chromatography coupled with diode array detector and Q-Exactive Orbitrap tandem mass spectrometry Biomed Chromatogr. 2018 May 3:e4272. doi: 10.1002/bmc.4272.

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