Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001734)
Formula Reactant Niclosamide Product 3-hydroxy niclosamide
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 1A2 (CYP1A2) DME Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001735 Niclosamide Niclosamide-2-O-glucuronide metabolite Conjugation - Glucuronidation Niclosamide [1]
References
1 Metabolism of the anthelmintic drug niclosamide by cytochrome P450 enzymes and UDP-glucuronosyltransferases: metabolite elucidation and main contributions from CYP1A2 and UGT1A1 Xenobiotica. 2016;46(1):1-13. doi: 10.3109/00498254.2015.1047812.

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