Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001764)
Formula Reactant Nitrofurantoin Product Nitrofurantoin metabolite M10
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A5 (CYP3A5) DME Info
Cytochrome P450 2A6 (CYP2A6) DME Info
Metabolic Type Oxidation - Oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001767 Nitrofurantoin Aminofurantoin Unclear Nitrofurantoin [1]
MR001765 Nitrofurantoin Nitrofurantoin metabolite 8(M1/M2) Oxidation - Oxidation Nitrofurantoin [2]
MR001766 Nitrofurantoin Nitrofurantoin metabolite 9(M1/M2) Oxidation - Oxidation Nitrofurantoin [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001762 Nitrofurantoin metabolite M10 Nitrofurantoin metabolite 8(M1/M2) Oxidation - Oxidation Nitrofurantoin [2]
MR001763 Nitrofurantoin metabolite M10 Nitrofurantoin metabolite 9(M1/M2) Oxidation - Oxidation Nitrofurantoin [2]
References
1 Nitrofurantoin disposition Clin Pharmacol Ther. 1981 Jun;29(6):808-16. doi: 10.1038/clpt.1981.115.
2 Oxidative bioactivation of nitrofurantoin in rat liver microsomes Xenobiotica. 2017 Feb;47(2):103-111. doi: 10.3109/00498254.2016.1164913.

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