Details of the Drug Metabolite (DM) | INTEDE

General Information of Drug Metabolite (DM) (ID: DM002218)
DM Name	Nitrofurantoin metabolite 8(M1/M2)

Full List of Drug-Metabolizing Enzyme (DME) Related to This DM

DME(s) Producing This DM through Metabolism

DME Name	DME ID	Reactant	Reaction	Related Drug	REF
Cytochrome P450 2A6 (CYP2A6)	DME0005	Nitrofurantoin metabolite M10	Oxidation - Oxidation	Nitrofurantoin	[1]
Cytochrome P450 2A6 (CYP2A6)	DME0005	Nitrofurantoin	Oxidation - Oxidation	Nitrofurantoin	[1]
Cytochrome P450 3A5 (CYP3A5)	DME0012	Nitrofurantoin metabolite M10	Oxidation - Oxidation	Nitrofurantoin	[1]
Cytochrome P450 3A5 (CYP3A5)	DME0012	Nitrofurantoin	Oxidation - Oxidation	Nitrofurantoin	[1]

Full List of Drug(s) That Produce This DM By Metabolism
Nitrofurantoin		DR1169	Approved		Infectious cystitis

References
1	Oxidative bioactivation of nitrofurantoin in rat liver microsomes Xenobiotica. 2017 Feb;47(2):103-111. doi: 10.3109/00498254.2016.1164913.

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