Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001782)
Formula
SVG example
Reactant Norethindrone acetate Product 5beta-dihydronorethisteronee
Reactant Info Product Info
Metabolic Enzyme Aldo-keto reductase 1D1 (AKR1D1) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001781 Norethindrone acetate 5alpha-dihydronorethisterone Reduction - Reduction Norethindrone acetate [1], [2]
MR001783 Norethindrone acetate Norethindrone acetate metabolite M1,M2 Oxidation - Hydroxylation Norethindrone acetate [3]
MR001784 Norethindrone acetate Norethindrone acetate metabolite M4 Oxidation - Dehydrogenation Norethindrone acetate [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001779 5beta-dihydronorethisteronee 3alpha,5beta-tetrahydronorethisterone Reduction - Reduction Norethindrone acetate [2]
MR001778 5beta-dihydronorethisteronee 3beta,5beta-tetrahydronorethisterone Reduction - Reduction Norethindrone acetate [2]
References
1 Tibolone and its delta-4, 7alpha-methyl norethisterone metabolite are reversible inhibitors of human aromatase J Steroid Biochem Mol Biol. 2007 May;104(3-5):154-60. doi: 10.1016/j.jsbmb.2007.03.027.
2 Hormonal properties of norethisterone, 7alpha-methyl-norethisterone and their derivatives. J Steroid Biochem Mol Biol. 2000 Nov 15;74(4):213-22.
3 Identification of the human cytochrome P450 enzymes involved in the in vitro biotransformation of lynestrenol and norethindrone. J Steroid Biochem Mol Biol. 2008 May;110(1-2):56-66.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.