Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001783)
Formula Reactant Norethindrone acetate Product Norethindrone acetate metabolite M1,M2
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001781 Norethindrone acetate 5alpha-dihydronorethisterone Reduction - Reduction Norethindrone acetate [1], [2]
MR001782 Norethindrone acetate 5beta-dihydronorethisteronee Unclear Norethindrone acetate [2]
MR001784 Norethindrone acetate Norethindrone acetate metabolite M4 Oxidation - Dehydrogenation Norethindrone acetate [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001780 Norethindrone acetate metabolite M1,M2 Norethindrone acetate metabolite M3 Oxidation - Dihydroxylation Norethindrone acetate [3]
References
1 Tibolone and its delta-4, 7alpha-methyl norethisterone metabolite are reversible inhibitors of human aromatase J Steroid Biochem Mol Biol. 2007 May;104(3-5):154-60. doi: 10.1016/j.jsbmb.2007.03.027.
2 Hormonal properties of norethisterone, 7alpha-methyl-norethisterone and their derivatives. J Steroid Biochem Mol Biol. 2000 Nov 15;74(4):213-22.
3 Identification of the human cytochrome P450 enzymes involved in the in vitro biotransformation of lynestrenol and norethindrone. J Steroid Biochem Mol Biol. 2008 May;110(1-2):56-66.

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