Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001803)
Formula
SVG example
N-Demethylation
Reactant Olanzapine Product 4'-N-desmethylolanzapine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 1A2 (CYP1A2) DME Info
Metabolic Type Oxidation - N-Demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001804 Olanzapine 2-hydroxymethylolanzapine Unclear Olanzapine [1], [2], [3]
MR001802 Olanzapine 7-hydroxyolanzapine Oxidation - 7-Hydroxylation Olanzapine [1], [2]
MR001806 Olanzapine N-oxide olanzapine metabolite Oxidation - N-Oxidation Olanzapine [1], [3]
MR001805 Olanzapine Olanzapine 10-N-glucuronide metabolite Conjugation - Glucuronidation Olanzapine [1], [2]
References
1 Olanzapine. Pharmacokinetic and pharmacodynamic profile. Clin Pharmacokinet. 1999 Sep;37(3):177-93.
2 The Unique Human N10-Glucuronidated Metabolite Formation from Olanzapine in Chimeric NOG-TKm30 Mice with Humanized Livers. Drug Metab Dispos. 2023 Apr;51(4):480-491. doi: 10.1124/dmd.122.001102.
3 Quantification of olanzapine and its three metabolites by liquid chromatography-tandem mass spectrometry in human body fluids obtained from four deceased, and confirmation of the reduction from olanzapine N-oxide to olanzapine in whole blood in vitro. Forensic Toxicol. 2023 Jul;41(2):318-328. doi: 10.1007/s11419-023-00662-0.

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