Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001804)
Formula
SVG example
Reactant Olanzapine Product 2-hydroxymethylolanzapine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2D6 (CYP2D6) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001803 Olanzapine 4'-N-desmethylolanzapine Oxidation - N-Demethylation Olanzapine [1], [2]
MR001802 Olanzapine 7-hydroxyolanzapine Oxidation - 7-Hydroxylation Olanzapine [1], [2]
MR001806 Olanzapine N-oxide olanzapine metabolite Oxidation - N-Oxidation Olanzapine [1], [3]
MR001805 Olanzapine Olanzapine 10-N-glucuronide metabolite Conjugation - Glucuronidation Olanzapine [1], [2]
References
1 Olanzapine. Pharmacokinetic and pharmacodynamic profile. Clin Pharmacokinet. 1999 Sep;37(3):177-93.
2 The Unique Human N10-Glucuronidated Metabolite Formation from Olanzapine in Chimeric NOG-TKm30 Mice with Humanized Livers. Drug Metab Dispos. 2023 Apr;51(4):480-491. doi: 10.1124/dmd.122.001102.
3 Quantification of olanzapine and its three metabolites by liquid chromatography-tandem mass spectrometry in human body fluids obtained from four deceased, and confirmation of the reduction from olanzapine N-oxide to olanzapine in whole blood in vitro. Forensic Toxicol. 2023 Jul;41(2):318-328. doi: 10.1007/s11419-023-00662-0.

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