Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001821)
Formula
SVG example
N-Demethylation
Reactant Olopatadine Product N-desmethyl olopatadine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - N-Demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001822 Olopatadine Olopatadine metabolite M5 Conjugation - Sulfation Olopatadine [1]
MR001823 Olopatadine Olopatadine N-oxide metabolite Unclear Olopatadine [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001819 N-desmethyl olopatadine Olopatadine metabolite M2 Unclear Olopatadine [1]
References
1 Effects of olopatadine, a new antiallergic agent, on human liver microsomal cytochrome P450 activities. Drug Metab Dispos. 2002 Dec;30(12):1504-11.
2 U. S. FDA Label -Olopatadine

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