Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001857)
Formula
CYP3A4 ...
SVG example
Reactant Ospemifene Product 4-hydroxylation Ospemifene
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2C9 (CYP2C9) DME Info
Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Cytochrome P450 2B6 (CYP2B6) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001859 Ospemifene 3-hydroxylation Ospemifene Unclear Ospemifene [1]
MR001860 Ospemifene 4'-hydroxylation Ospermifene Unclear Ospemifene [1]
MR001858 Ospemifene Ospemifene carboxylic acid Unclear Ospemifene [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001855 4-hydroxylation Ospemifene 4-hydroxycarboxylic acid Unclear Ospemifene [1]
References
1 Ospemifene metabolism in humans in vitro and in vivo: metabolite identification, quantitation, and CYP assignment of major hydroxylations. Drug Metabol Drug Interact. 2013;28(3):153-61.

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