Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001871)
Formula
AKR1C1 ...
SVG example
Reduction
Reactant Oxcarbazepine Product Eslicarbazepine
Reactant Info Product Info
Metabolic Enzyme Aldo-keto reductase 1C1 (AKR1C1) DME Info
Aldo-keto reductase 1C2 (AKR1C2) DME Info
Aldo-keto reductase 1C3 (AKR1C3) DME Info
Aldo-keto reductase 1C4 (AKR1C4) DME Info
Metabolic Type Reduction - Reduction
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001869 Oxcarbazepine Oxcarbazepine alcohol sulfate Conjugation - Sulfation Oxcarbazepine [1]
MR001870 Oxcarbazepine Oxcarbazepine glucuronide Conjugation - O-Glucuronidation Oxcarbazepine [1]
MR001872 Oxcarbazepine R-licarbazepine Reduction - Reduction Oxcarbazepine [2]
MR000949 Oxcarbazepine 10-hydroxycarbazepine glucuronide metabolite Unclear Eslicarbazepine acetate [3]
MR000947 Oxcarbazepine Oxcarbazepine alcohol sulfate Unclear Eslicarbazepine acetate [3]
MR000950 Oxcarbazepine R-licarbazepine Reduction - Reduction Eslicarbazepine acetate [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000946 Eslicarbazepine acetate Eslicarbazepine Unclear Eslicarbazepine acetate [4]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000945 Eslicarbazepine Eslicarbazepine-O-glucuronide metabolite Unclear Eslicarbazepine acetate [4], [5]
MR000944 Eslicarbazepine Oxcarbazepine Oxidation - Oxidation Eslicarbazepine acetate [4], [5]
References
1 The metabolism of 14C-oxcarbazepine in man Xenobiotica. 1986 Aug;16(8):769-78. doi: 10.3109/00498258609043567.
2 The role of carbonyl reducing enzymes in oxcarbazepine in vitro metabolism in man. Chem Biol Interact. 2014 Sep 5;220:241-7.
3 U. S. FDA Label -Eslicarbazepine acetate
4 Pharmacokinetics and drug interactions of eslicarbazepine acetate Epilepsia. 2012 Jun;53(6):935-46. doi: 10.1111/j.1528-1167.2012.03519.x.
5 Key factors in the discovery and development of new antiepileptic drugs Nat Rev Drug Discov. 2010 Jan;9(1):68-82. doi: 10.1038/nrd2997.

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