Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001872)
Formula
AKR1C1 ...
SVG example
Reduction
Reactant Oxcarbazepine Product R-licarbazepine
Reactant Info Product Info
Metabolic Enzyme Aldo-keto reductase 1C1 (AKR1C1) DME Info
Aldo-keto reductase 1C2 (AKR1C2) DME Info
Aldo-keto reductase 1C3 (AKR1C3) DME Info
Aldo-keto reductase 1C4 (AKR1C4) DME Info
Metabolic Type Reduction - Reduction
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001871 Oxcarbazepine Eslicarbazepine Reduction - Reduction Oxcarbazepine [1]
MR001869 Oxcarbazepine Oxcarbazepine alcohol sulfate Conjugation - Sulfation Oxcarbazepine [2]
MR001870 Oxcarbazepine Oxcarbazepine glucuronide Conjugation - O-Glucuronidation Oxcarbazepine [2]
MR000949 Oxcarbazepine 10-hydroxycarbazepine glucuronide metabolite Unclear Eslicarbazepine acetate [3]
MR000948 Oxcarbazepine Eslicarbazepine Reduction - Reduction Eslicarbazepine acetate [3]
MR000947 Oxcarbazepine Oxcarbazepine alcohol sulfate Unclear Eslicarbazepine acetate [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001866 R-licarbazepine Cis-10,11-Dihydroxy-10,11-dihydrocarbamazepine Oxidation - Oxidation Oxcarbazepine [4]
MR001865 R-licarbazepine R-Licarbazepine glucuronide Conjugation - O-Glucuronidation Oxcarbazepine [4]
MR001868 R-licarbazepine S-Licarbazepine glucuronide Conjugation - O-Glucuronidation Oxcarbazepine [4]
MR001867 R-licarbazepine Trans-10,11-dihydro-10,11-dihydroxycarbamazepine Oxidation - Oxidation Oxcarbazepine [4]
References
1 The role of carbonyl reducing enzymes in oxcarbazepine in vitro metabolism in man. Chem Biol Interact. 2014 Sep 5;220:241-7.
2 The metabolism of 14C-oxcarbazepine in man Xenobiotica. 1986 Aug;16(8):769-78. doi: 10.3109/00498258609043567.
3 U. S. FDA Label -Eslicarbazepine acetate
4 DrugBank(Pharmacology-Metabolism)Oxcarbazepine

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