Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001876)
Formula
SVG example
Reactant N-desethyloxybutynin Product 2-Cyclohexyl-2-hydroxy-2-phenylacetic acid
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012383 (S)-oxybutynin Oxy-DE Unclear - Unclear (S)-oxybutynin [1]
MR001877 Oxybutynin chloride N-desethyloxybutynin Oxidation - N-Deethylation Oxybutynin chloride [2], [3]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012387 Oxy-DE (S)-oxybutynin M4,M5 Unclear - Unclear (S)-oxybutynin [1]
MR012386 Oxy-DE (S)-oxybutynin M6 Unclear - Unclear (S)-oxybutynin [1]
MR012384 Oxy-DE Oxy-HA Unclear - Unclear (S)-oxybutynin [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012392 (S)-oxybutynin CHMA Unclear - Unclear (S)-oxybutynin [1]
References
1 New insights in the metabolism of oxybutynin: evidence of N-oxidation of propargylamine moiety and rearrangement to enaminoketone
2 Oxybutynin. A review of its pharmacodynamic and pharmacokinetic properties, and its therapeutic use in detrusor instability Drugs Aging. 1995 Mar;6(3):243-62. doi: 10.2165/00002512-199506030-00007.
3 Stereoselective pharmacokinetics of oxybutynin and N-desethyloxybutynin in vitro and in vivo. Xenobiotica. 2007 Jan;37(1):59-73.

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