Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001877)
Formula
CYP3A4 ...
SVG example
N-Deethylation
Reactant Oxybutynin chloride Product N-desethyloxybutynin
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Metabolic Type Oxidation - N-Deethylation
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012383 (S)-oxybutynin Oxy-DE Unclear - Unclear (S)-oxybutynin [1]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012387 Oxy-DE (S)-oxybutynin M4,M5 Unclear - Unclear (S)-oxybutynin [1]
MR012386 Oxy-DE (S)-oxybutynin M6 Unclear - Unclear (S)-oxybutynin [1]
MR001876 N-desethyloxybutynin 2-Cyclohexyl-2-hydroxy-2-phenylacetic acid Unclear Oxybutynin chloride [2]
MR012384 Oxy-DE Oxy-HA Unclear - Unclear (S)-oxybutynin [1]
References
1 New insights in the metabolism of oxybutynin: evidence of N-oxidation of propargylamine moiety and rearrangement to enaminoketone
2 Oxybutynin. A review of its pharmacodynamic and pharmacokinetic properties, and its therapeutic use in detrusor instability Drugs Aging. 1995 Mar;6(3):243-62. doi: 10.2165/00002512-199506030-00007.

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