Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001937)
Formula
CYP3A4 ...
SVG example
Reactant Panobinostat lactate Product Panobinostat lactate metabolite M5
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2D6 (CYP2D6) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001936 Panobinostat lactate Panobinostat lactate metabolite M1 Unclear Panobinostat lactate [1]
MR001935 Panobinostat lactate Panobinostat lactate metabolite M4 Unclear Panobinostat lactate [1]
MR001934 Panobinostat lactate Panobinostat lactate metabolite M6 Unclear Panobinostat lactate [1]
References
1 Biocatalytic synthesis and structure elucidation of cyclized metabolites of the deacetylase inhibitor panobinostat (LBH589) Drug Metab Dispos. 2012 May;40(5):1041-50. doi: 10.1124/dmd.111.043620.

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