Details of the Metabolic Reaction (MR) | INTEDE

General Information of This Metabolic Reaction (MR) (ID: MR001983)
Formula	Oxidation
	Reactant	Pentoxifylline		Product	Pentoxifylline metabolite M5
	Reactant	Reactant Info		Product	Product Info
Metabolic Type	Oxidation - Oxidation

Other MR(s) Related to The Reactant of This MR

Other MR(s) That Metabolize The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR001981	Pentoxifylline	Lisofylline	Reduction - Reduction	Pentoxifylline	[1]
MR001982	Pentoxifylline	Pentoxifylline metabolite (S) M1	Reduction - Reduction	Pentoxifylline	[1], [2]
MR001984	Pentoxifylline	Pentoxifylline metabolite M6	Oxidation - Demethylation	Pentoxifylline	[3]

References
1	Metabolism of lisofylline and pentoxifylline in human liver microsomes and cytosol Drug Metab Dispos. 1996 Nov;24(11):1174-9.
2	Stereoselective metabolism of pentoxifylline in vitro and in vivo in humans Chirality. 2002 Aug;14(8):643-52. doi: 10.1002/chir.10121.
3	Role of CYP1A2 and CYP2E1 in the pentoxifylline ciprofloxacin drug interaction Biochem Pharmacol. 2004 Jul 15;68(2):395-402. doi: 10.1016/j.bcp.2004.03.035.

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