Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001984)
Formula
SVG example
Demethylation
Reactant Pentoxifylline Product Pentoxifylline metabolite M6
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 1A2 (CYP1A2) DME Info
Metabolic Type Oxidation - Demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001981 Pentoxifylline Lisofylline Reduction - Reduction Pentoxifylline [1]
MR001982 Pentoxifylline Pentoxifylline metabolite (S) M1 Reduction - Reduction Pentoxifylline [1], [2]
MR001983 Pentoxifylline Pentoxifylline metabolite M5 Oxidation - Oxidation Pentoxifylline [2]
References
1 Metabolism of lisofylline and pentoxifylline in human liver microsomes and cytosol Drug Metab Dispos. 1996 Nov;24(11):1174-9.
2 Stereoselective metabolism of pentoxifylline in vitro and in vivo in humans Chirality. 2002 Aug;14(8):643-52. doi: 10.1002/chir.10121.

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