Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001981)
Formula
SVG example
Reduction
Reactant Pentoxifylline Product Lisofylline
Reactant Info Product Info
Metabolic Type Reduction - Reduction
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001982 Pentoxifylline Pentoxifylline metabolite (S) M1 Reduction - Reduction Pentoxifylline [1], [2]
MR001983 Pentoxifylline Pentoxifylline metabolite M5 Oxidation - Oxidation Pentoxifylline [2]
MR001984 Pentoxifylline Pentoxifylline metabolite M6 Oxidation - Demethylation Pentoxifylline [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001980 Lisofylline Pentoxifylline metabolite M2 Oxidation - Hydroxylation Pentoxifylline [1]
MR001979 Lisofylline Pentoxifylline metabolite M3 Oxidation - Hydroxylation Pentoxifylline [1]
MR001978 Lisofylline Pentoxifylline metabolite M7 Oxidation - Demethylation Pentoxifylline [1]
References
1 Metabolism of lisofylline and pentoxifylline in human liver microsomes and cytosol Drug Metab Dispos. 1996 Nov;24(11):1174-9.
2 Stereoselective metabolism of pentoxifylline in vitro and in vivo in humans Chirality. 2002 Aug;14(8):643-52. doi: 10.1002/chir.10121.
3 Role of CYP1A2 and CYP2E1 in the pentoxifylline ciprofloxacin drug interaction Biochem Pharmacol. 2004 Jul 15;68(2):395-402. doi: 10.1016/j.bcp.2004.03.035.

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