Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001986)
Formula Reactant Perazine Product N-desmethylperazine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2C9 (CYP2C9) DME Info
Metabolic Type Oxidation - N-Demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001988 Perazine Hydroxyperazine Unclear Perazine [1]
MR001987 Perazine Perazine 5-sulfoxide metabolite Oxidation - Sulphoxidation Perazine [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001985 N-desmethylperazine N-{3-(phenothiazinyl-10)-propyl}ethylenediamine Oxidation - N-Dealkylation Perazine [1]
References
1 The metabolism of the piperazine-type phenothiazine neuroleptic perazine by the human cytochrome P-450 isoenzymes. Eur Neuropsychopharmacol. 2004 May;14(3):199-208.

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