Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001985)
Formula Reactant N-desmethylperazine Product N-{3-(phenothiazinyl-10)-propyl}ethylenediamine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Cytochrome P450 1A2 (CYP1A2) DME Info
Metabolic Type Oxidation - N-Dealkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001986 Perazine N-desmethylperazine Oxidation - N-Demethylation Perazine [1]
References
1 The metabolism of the piperazine-type phenothiazine neuroleptic perazine by the human cytochrome P-450 isoenzymes. Eur Neuropsychopharmacol. 2004 May;14(3):199-208.

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