Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001990)
Formula
SVG example
Demethylation
Reactant Pergolide mesylate Product N-Despropyl Pergolide
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - Demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001991 Pergolide mesylate Pergolide sulfone Reduction - Reduction Pergolide mesylate [1]
MR001992 Pergolide mesylate Pergolide sulfoxide Reduction - Reduction Pergolide mesylate [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001989 N-Despropyl Pergolide 1,6-Bis-boc Despropyl Pergolide Sulfoxide Reduction - Reduction Pergolide mesylate [1]
References
1 Dopamine agonist activities of pergolide, its metabolites, and bromocriptine as measured by prolactin inhibition, compulsive turning, and stereotypic behavior Arzneimittelforschung. 1993 Mar;43(3):281-6.

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