Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002031)
Formula
UGT1A1 ...
SVG example
O-Glucuronidation
Reactant Hydroxyphenytoin Product 4-hydroxyphenytoin o-glucuronide
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 1A1 (UGT1A1) DME Info
UDP-glucuronosyltransferase 1A4 (UGT1A4) DME Info
UDP-glucuronosyltransferase 1A6 (UGT1A6) DME Info
UDP-glucuronosyltransferase 1A9 (UGT1A9) DME Info
Metabolic Type Conjugation - O-Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002029 Phenytoin arene-oxide Hydroxyphenytoin Unclear Phenytoin [1]
MR003162 Phenytoin arene-oxide Hydroxyphenytoin Unclear Fosphenytoin sodium [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002030 Hydroxyphenytoin Phenytoin catechol Oxidation - Oxidation Phenytoin [1]
MR003165 Hydroxyphenytoin Hydroxyphenytoin-O-glucuronide metabolite Unclear Fosphenytoin sodium [2]
MR003164 Hydroxyphenytoin Phenytoin catechol Oxidation - Oxidation Fosphenytoin sodium [1]
References
1 Pharmacogenomics knowledge for personalized medicine Clin Pharmacol Ther. 2012 Oct;92(4):414-7. doi: 10.1038/clpt.2012.96.
2 U. S. FDA Label -Fosphenytoin sodium

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.