Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002030)
Formula
CYP3A4 ...
SVG example
Oxidation
Reactant Hydroxyphenytoin Product Phenytoin catechol
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Cytochrome P450 3A7 (CYP3A7) DME Info
Cytochrome P450 2C9 (CYP2C9) DME Info
Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Cytochrome P450 2B6 (CYP2B6) DME Info
Cytochrome P450 2D6 (CYP2D6) DME Info
Metabolic Type Oxidation - Oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002029 Phenytoin arene-oxide Hydroxyphenytoin Unclear Phenytoin [1]
MR003162 Phenytoin arene-oxide Hydroxyphenytoin Unclear Fosphenytoin sodium [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002031 Hydroxyphenytoin 4-hydroxyphenytoin o-glucuronide Conjugation - O-Glucuronidation Phenytoin [1], [2]
MR003165 Hydroxyphenytoin Hydroxyphenytoin-O-glucuronide metabolite Unclear Fosphenytoin sodium [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002034 Phenytoin dihydrodiol Phenytoin catechol Unclear Phenytoin [4]
MR003169 Phenytoin dihydrodiol Phenytoin catechol Unclear Fosphenytoin sodium [5]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002032 Phenytoin catechol Phenytoin methylcatechol Conjugation - Methylation Phenytoin [1]
MR002033 Phenytoin catechol Phenytoin quinone Oxidation - Oxidation Phenytoin [1]
MR003166 Phenytoin catechol Phenytoin methylcatechol Conjugation - Methylation Fosphenytoin sodium [5]
MR003167 Phenytoin catechol Phenytoin quinone Oxidation - Oxidation Fosphenytoin sodium [5]
References
1 Pharmacogenomics knowledge for personalized medicine Clin Pharmacol Ther. 2012 Oct;92(4):414-7. doi: 10.1038/clpt.2012.96.
2 Biotransformation of phenytoin in the electrochemically-driven CYP2C19 system. Biophys Chem. 2022 Dec;291:106894. doi: 10.1016/j.bpc.2022.106894.
3 U. S. FDA Label -Fosphenytoin sodium
4 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
5 DrugBank(Pharmacology-Metabolism)Fosphenytoin sodium

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